A synthetic model of human T-cell acute lymphoblastic leukemia in primary cord blood cells.
A synthetic model of human T-cell acute lymphoblastic leukemia in primary cord blood cells.
批准号:
367344
负责人:
Sun Chong
金额:
$1.27万
依托单位国家:
加拿大
项目类别:
Studentship Programs
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-12-01 至 2017-12-01
中文摘要
T细胞急性淋巴细胞白血病(T-ALL)的正常造血祖细胞向恶性、未成熟T细胞母细胞的白血病发生依赖于多种遗传病变的协同作用。Notch 1、LMO 2和TAL 1都是常见的癌基因。
英文摘要
The leukemogenesis of normal hematopoietic progenitors into the malignant, immature T-cell blasts of T-cell acute lymphoblastic leukemia (T-ALL) is dependent on the cooperative effect of many genetic lesions. Notch1, LMO2, and TAL1 are all oncogenes frequ
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会议论文
De-constructing Oncogenic Effectors in a Synthetic Model of Human T-cell Acute Lymphoblastic Leukemia
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批准号:383404
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项目类别:Studentship Programs
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资助金额:$7.65万
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财政年份:2017
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负责人:Sun Chong
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依托单位:
海外基金