Characterization of recombinant human mitochondrial processing peptidase

重组人线粒体加工肽酶的表征

• 批准号: 367050
• 负责人: Bayne Andrew
• 金额: $ 1.27万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-12-01 至 2017-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=367050&lang=en
• 关键词: Mitochondria; Mitochondrial Processing Peptidase; Mitochondrial Quality Control; Mitophagy; Mpp; Neurodegeneration; Parkinson'S Disease; Pink1 Proteolysis; Protein Import; Structural Biology

The vast majority of mitochondrial proteins are synthesized in the cytosol and must be transported into the mitochondria. These proteins are targeted by a short signal peptide which must be removed once they are at the mitochondrial membrane. This removal

绝大多数线粒体蛋白是在胞浆中合成的，必须运输到线粒体中。这些蛋白质是以短信号肽为靶标的，一旦它们到达线粒体膜，就必须将其移除。此删除