Pancreatic PHIP-mediated control of í-cell survival and inflammatory responses

胰腺 PHIP 介导的 α 细胞存活和炎症反应的控制

• 批准号: 367155
• 负责人: Jain Srishti
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-12-01 至 2017-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=367155&lang=en
• 关键词: Bromodomains; Cre/Lox Mouse Models; Epigenetics; Growth/Survival Pathways; Islet Inflammation; Phip; Proteomics; Transcriptomics; Type 1 Diabetes; Í-Cells

DNA is tightly wrapped around proteins to form a compact structure called chromatin. Chemical groups added to chromatin can turn the expression of nearby genes on or off, and several proteins read, add or remove these epigenetic marks. Increasing evidence

DNA 紧紧包裹在蛋白质周围，形成称为染色质的紧凑结构。添加到染色质中的化学基团可以打开或关闭附近基因的表达，并且有几种蛋白质可以读取、添加或删除这些表观遗传标记。越来越多的证据