Influence of pre-existing HIV cross-reactive CD4 T cells on vaccine responses to new Env immunogens

现有 HIV 交叉反应 CD4 T 细胞对新 Env 免疫原疫苗反应的影响

• 批准号: 365740
• 负责人: Kaufmann Daniel E
• 金额: $ 18.21万
• 依托单位: Centre hospitalier de l'Universit de Montral (CHUM)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-02-01 至 2018-08-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=365740&lang=en
• 关键词: Antibody; Cd4 T Cell; Hiv; Immune Repertoire; Immunogen Design; Immunogeneicity; T Cell Memory; Vaccine

It is widely assumed that a successful HIV vaccine will elicit protective antibodies to prevent infection. The development of potent antibodies is regulated by a population of white blood cells called CD4 T cells. These CD4 T cells must recognize parts of

人们普遍认为，一个成功的艾滋病毒疫苗将引发保护性抗体，以防止感染。有效抗体的产生是由一群称为CD4 T细胞的白色血细胞调节的。这些CD4 T细胞必须识别