Pathway Maps of Transcription Factors

转录因子的通路图

• 批准号: RGPIN-2016-06485
• 负责人: Reimand, Jüri
• 金额: $ 2.62万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628813
• 关键词: Pathway; Maps; Transcription; Factors

Gene regulation is a process in cells that turns genes on and off at the right place and time. A special type of genes called transcription factors (TFs) carries out this process. TF proteins recognize genes in DNA and make them active or disabled. TFs are very important because all vital parts and activities of cells depend on exact sets of genes being active. However, there are thousands of TFs in humans and other organisms and we still do not know all the genes they regulate. Although scientists are collecting large amounts of information to understand TFs, the collected information is often incomplete and has biases and errors. Analysing many types of evidence about genes and TFs at the same time can overcome these limitations and lead to a wide range of new insights into TF function.

基因调控是细胞中在正确的地点和时间开启和关闭基因的过程。一种名为转录因子(TF)的特殊类型的基因执行这一过程。转铁蛋白识别DNA中的基因，并使其激活或禁用。转铁蛋白是非常重要的，因为细胞的所有重要部分和活动都依赖于被激活的精确的基因集合。然而，在人类和其他生物体中有成千上万的转录因子，我们仍然不知道它们调控的所有基因。尽管科学家们正在收集大量信息来了解TFS，但收集的信息往往是不完整的，存在偏见和错误。同时分析关于基因和转铁蛋白的多种证据可以克服这些限制，并导致对转铁蛋白功能的广泛的新的见解。