A systematic genome wide effort to identify and validate targetable synthetic dosage lethal interactions of mitotic kinases in colorectal cancer cells

系统性全基因组工作，旨在识别和验证结直肠癌细胞中有丝分裂激酶的靶向合成剂量致死相互作用

• 批准号: 369423
• 负责人: Vizeacoumar Franco J
• 金额: $ 43.19万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-09-01 至 2022-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=369423&lang=en
• 关键词: Chromosomal Instability; Crispr-Cas9-Based Target Validation; Genetic Interactions; Genomics; Pooled Shrna Screening; Synthetic Dosage Lethality

Cancer cells often overexpress specific genes due to the effect of translocations, gene amplification, or other epigenetic modifications. Researchers have thought that directly inhibiting the function of these overexpressing genes could help to eliminate

由于易位、基因扩增或其他表观遗传修饰的影响，癌细胞通常过表达特定基因。研究人员认为，直接抑制这些过度表达基因的功能可能有助于消除