Tools to decipher neuronal signaling and compoutation

破译神经元信号和计算的工具

• 批准号: RGPIN-2015-04499
• 负责人: DeKoninck, Yves
• 金额: $ 7.43万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628824
• 关键词: Tools; decipher; neuronal; signaling; compoutation

The objective of my NSERC program is to understand the biophysical determinants of neural signalling and computation. That is, to identify the substrates of cell to cell signalling and of signal integration that underlie information processing in neural circuits. In this context, my research has focused on 1) how the structural and functional organizations of synapses affects information transfer between cells and 2) how synaptic mechanisms interact with the intrinsic properties of nerve cells to shape information coding. To achieve this, I continuously seek to develop novel, enabling approaches and analytical tools. We develop: 1) signal analysis tools to resolve biophysical events at the limits of what our experimental tools allow us to address, 2) novel, high-resolution microscopy and nanotechnology tools to resolve structural determinants underlying synaptic arrangements, and 3) computer-based modeling to identify how synaptic mechanisms determine information coding by individual neurons and small neural circuits.

我的NSERC计划的目标是了解神经信号和计算的生物物理决定因素。也就是说，识别细胞到细胞的信号传导和信号整合的基底，这些基底是神经回路中信息处理的基础。在这种情况下，我的研究集中在1）突触的结构和功能组织如何影响细胞之间的信息传递和2）突触机制如何与神经细胞的内在属性相互作用，以塑造信息编码。为了实现这一目标，我不断寻求开发新的，使能的方法和分析工具。我们开发：1）信号分析工具，以解决我们的实验工具允许我们解决的极限生物物理事件，2）新的，高分辨率显微镜和纳米技术工具，以解决突触排列的结构决定因素，以及3）基于计算机的建模，以确定突触机制如何确定单个神经元和小神经回路的信息编码。