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How enzymes break carbon-fluorine bonds

How enzymes break carbon-fluorine bonds
酶如何打破碳氟键
批准号:
RGPIN-2015-04877
负责人:
Pai, Emil
金额:
$2.77万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2018-12-31

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中文摘要
翻译
加拿大已经确定了22,000多个受污染或疑似受污染的地点并对其进行了分类。它们中的许多含有卤代烃,这些污染物对自然分解和补救工作具有很强的抵抗力。其中一些化合物甚至可以在北极熊的血液中找到。脱卤酶是一种打破碳-卤键的酶;它们正在接受测试,以修复这些受污染的部位。通过我们的工作,我们打算改进这些蛋白质作为更环保的补救手段的使用。
英文摘要
Canada has identified and classified over 22,000 contaminated or suspected contaminated sites. Many of them harbour halogenated hydrocarbons, contaminants that are highly resistant to natural breakdown as well as remediation efforts. Some of these compounds can even be found in the blood of polar bears. Dehalogenases are enzymes that break carbon-halogen bonds; they are being tested for restoring such contaminated sites. With our work, we intend to improve the use of these proteins as more environmentally friendly means of remediation.
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Time-resolved crystallography of enzyme-catalyzed reactions
  • 批准号:
    RGPIN-2020-06867
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $3.5万
  • 财政年份:
    2022
  • 负责人:
    Pai, Emil
  • 依托单位:
Time-resolved crystallography of enzyme-catalyzed reactions
  • 批准号:
    RGPIN-2020-06867
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $3.5万
  • 财政年份:
    2021
  • 负责人:
    Pai, Emil
  • 依托单位:
Time-resolved crystallography of enzyme-catalyzed reactions
  • 批准号:
    RGPIN-2020-06867
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $3.5万
  • 财政年份:
    2020
  • 负责人:
    Pai, Emil
  • 依托单位:
How enzymes break carbon-fluorine bonds
  • 批准号:
    RGPIN-2015-04877
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.77万
  • 财政年份:
    2019
  • 负责人:
    Pai, Emil
  • 依托单位:
海外基金