How enzymes break carbon-fluorine bonds

酶如何打破碳氟键

• 批准号: RGPIN-2015-04877
• 负责人: Pai, Emil
• 金额: $ 2.77万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628842
• 关键词: How; enzymes; break; carbon; fluorine

Canada has identified and classified over 22,000 contaminated or suspected contaminated sites. Many of them harbour halogenated hydrocarbons, contaminants that are highly resistant to natural breakdown as well as remediation efforts. Some of these compounds can even be found in the blood of polar bears. Dehalogenases are enzymes that break carbon-halogen bonds; they are being tested for restoring such contaminated sites. With our work, we intend to improve the use of these proteins as more environmentally friendly means of remediation.

加拿大已查明22，000多个受污染或疑似受污染的场址并进行了分类。其中许多含有卤代烃，这种污染物很难自然分解，也很难进行补救。其中一些化合物甚至可以在北极熊的血液中找到。脱卤酶是一种能破坏碳-卤键的酶，目前正在测试它们是否能修复这些受污染的场地。通过我们的工作，我们打算改善这些蛋白质的使用，作为更环保的补救手段。