Proteomic investigation of alternative splicing in the control of cell differentiation

选择性剪接在真核生物蛋白质组多样性的产生中起着重要作用，因为在这个过程中，主要信使(Pre-mRNA)通过包含和排除特定的蛋白质编码外显子集而变成多个成熟的信使。在广泛的生物过程中，细胞分化需要选择性剪接。尽管它很重要，但在细胞分化过程中控制选择性剪接的确切机制仍然知之甚少。

Alternative splicing plays an important role in generating proteome diversity in eukaryotes, as primary messengers (pre-mRNA) turn into multiple mature messengers by inclusion and exclusion of specific sets of protein-coding exons during the process. Alternative splicing is required for cell differentiation in a wide range of biological processes. Despite its importance, the precise mechanisms controlling alternative splicing during cell differentiation remain poorly understood.