The Developmental Genetics of Brain-Body Allometry

脑体异速发育遗传学

• 批准号: RGPIN-2017-04851
• 负责人: Hallgrimsson, Benedikt
• 金额: $ 3.64万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628868
• 关键词: Developmental; Genetics; Brain; Body; Allometry

One of the most ubiquitous features of organismal variation is that shape correlates with size 1. This allometric variation is an example of integration or the tendency for traits to covary. Integration combined with genetic variation results in covariation among traits that enables but also restricts phenotypic responses to selection. Integration occurs when developmental processes drive variation in multiple traits. By channeling genetic and environmental influences, integration imparts structure on phenotypic covariation. Understanding this structure is key to one of the most difficult problems in modern biology – how development translates genetic to phenotypic variation in complex traits – a question to which modern genomic approaches have not yielded satisfactory answers.

生物体变异最普遍的特征之一是形状与尺寸1相关。这种异速生长变异是整合或性状协变趋势的一个例子。整合与遗传变异相结合，导致性状之间的协变，从而使选择的表型反应成为可能，但也限制了选择的表型反应。当发育过程驱动多种性状的变异时，整合就会发生。通过引导遗传和环境影响，整合赋予表型协变结构。理解这种结构是现代生物学中最困难的问题之一的关键--发育如何将复杂性状中的遗传变异转化为表型变异--现代基因组学方法还没有得到令人满意的答案。