Ancient biological functions of present day DNA-damaging enzymes involved in the immune system

当今免疫系统中 DNA 损伤酶的古老生物学功能

• 批准号: RGPIN-2015-04796
• 负责人: Larijani, Mani
• 金额: $ 2.19万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628870
• 关键词: Ancient; biological; functions; present; day

The goal of this research program is to understand forms and functions of DNA damaging processes in fish. The human immune system uses DNA damage in the form of mutations as well as double strand DNA breaks (DSBs) to initiate the diversification of antigen receptor genes in lymphocytes. Our central hypothesis is that orthologous version of these DNA damaging enzymes in fish are involved in biological roles beyond the immune system, possibly in epigenetic genome reprogramming and development.

这项研究计划的目标是了解鱼类DNA损伤过程的形式和功能。人类免疫系统使用突变和双链DNA断裂(DSB)形式的DNA损伤来启动淋巴细胞中抗原受体基因的多样化。我们的中心假设是，鱼类中这些DNA损伤酶的同源版本参与了免疫系统以外的生物角色，可能参与了表观基因组的重新编程和发育。