Differential regulation of the duplicated fatty acid-binding protein genes in teleost fishes

硬骨鱼中重复脂肪酸结合蛋白基因的差异调节

• 批准号: RGPIN-2017-05115
• 负责人: Wright, Jonathan
• 金额: $ 2.04万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628872
• 关键词: Differential; regulation; duplicated; fatty; acid

In 1970, Susumu Ohno proposed the major mechanism that facilitates increasing complexity in the evolution of life is gene duplication. Allan Force and others revisited this idea in the Duplication-Degeneration-Complementation (DDC) model in which duplicated genes are retained in the genome either by subfunctionalization, where the functions of the ancestral gene are sub-divided between the sister duplicate genes, or by neofunctionalization, where one of the duplicates acquires a new function. In this model, both processes for retention of duplicated genes occur by either loss or gain of regulatory elements in the promoters of sister duplicate genes. The common fate of a duplicated gene, however, is nonfunctionalization, the accumulation of deleterious mutations resulting in functional decay. The long-term goal of this research program is to test the hypothesis of the DDC model that duplicated genes are retained in the genome by either sub- or neofunctionalization. The work proposed in this Discovery Grant proposal focusses on the regulation of the duplicated copies of the multigene family of the intracellular lipid-binding protein (iLBP) genes that code for the fatty acid- (

1970年，大野进（Susumu Ohno）提出，在生命进化过程中，促进复杂性增加的主要机制是基因复制。艾伦·福斯（Allan Force）和其他人在复制-退化-互补（DDC）模型中重新审视了这一想法，在该模型中，复制的基因通过亚功能化（subfunctionalization）或新功能化（neofunctionalization）保留在基因组中，亚功能化是指祖先基因的功能在姐妹复制基因之间进行细分，新功能化是指其中一个复制基因获得新功能。在这个模型中，重复基因的保留过程都是通过姐妹重复基因启动子中调控元件的丢失或获得而发生的。然而，复制基因的共同命运是非功能化，即有害突变的积累导致功能衰退。这项研究计划的长期目标是测试DDC模型的假设，即重复的基因通过亚功能化或新功能化保留在基因组中。在这项发现资助计划中提出的工作重点是调节细胞内脂质结合蛋白（iLBP）基因的多基因家族的复制拷贝，该基因编码脂肪酸-（