Integrating and modeling host-microbiome interactions

宿主-微生物组相互作用的整合和建模

• 批准号: RGPIN-2016-05039
• 负责人: Langille, Morgan
• 金额: $ 2.19万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628882
• 关键词: Integrating; modeling; host; microbiome; interactions

“Microbiome” is a relatively new term to describe the entire set of microbes and their functions within a particular environment. Researchers are sampling various microbiomes including the ocean, soil, and host-associated (e.g. plant, animal and human). The host-associated microbiomes are crucial components of their hosts contributing metabolic capabilities, defence against unwanted pathogens, and training of the host immune system. These microbiomes are complex communities consisting of thousands of species and millions of genes that interact, not only amongst themselves, but also with their environment. To understand these interactions requires computational methods that help process large datasets and identify biologically relevant patterns. This research program pursues several new computational strategies for understanding the mechanisms within these microbial communities and how they interact with their hosts. In particular, it attempts to build methods that can predict when closely related microbes have different functional capabilities, improve host sample classification, and integrate information arising from diverse independent microbiome studies. This research program is crucial for leveraging the most knowledge from on-going microbiome research around the world and will provide the foundations for translating this knowledge into real world applications. These include more efficient and cost effective methods for profiling microbiomes, the ability to use the microbiome to improve diagnosis or treatment of various human diseases, and to identify novel microbes and microbial functions that are key determinants in host-microbial interactions.

“微生物组”是一个相对较新的术语，用于描述特定环境中的整套微生物及其功能。研究人员正在对各种微生物组进行采样，包括海洋，土壤和宿主相关（例如植物，动物和人类）。宿主相关的微生物组是其宿主的重要组成部分，有助于代谢能力，防御不想要的病原体，以及训练宿主免疫系统。这些微生物群是由数千个物种和数百万个基因组成的复杂群落，它们不仅相互作用，而且还与环境相互作用。为了理解这些相互作用，需要计算方法来帮助处理大型数据集并识别生物相关模式。这项研究计划追求几种新的计算策略，以了解这些微生物群落内的机制以及它们如何与宿主相互作用。特别是，它试图建立可以预测密切相关的微生物何时具有不同功能能力的方法，改进宿主样品分类，并整合来自不同独立微生物组研究的信息。这项研究计划对于利用世界各地正在进行的微生物组研究中的大多数知识至关重要，并将为将这些知识转化为真实的世界应用提供基础。这些包括用于分析微生物组的更有效和更具成本效益的方法，使用微生物组来改善各种人类疾病的诊断或治疗的能力，以及鉴定作为宿主-微生物相互作用的关键决定因素的新型微生物和微生物功能。