Molecular characterization of mixed-species bacterial biofilms in the gastrointestinal tract
胃肠道中混合物种细菌生物膜的分子特征
基本信息
- 批准号:RGPIN-2015-05243
- 负责人:
- 金额:$ 3.28万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2017
- 资助国家:加拿大
- 起止时间:2017-01-01 至 2018-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The gut microbiota (the community of microbes that colonizes the gastrointestinal tract) plays important roles in human health and disease, but little is known about the basic principles that underlie host-microbial symbiotic interactions in the vertebrate gut. In particular, the interactions between the bacterial members of multi-species intestinal biofilms have not been studied at all, but such knowledge is essential for the development of strategies that modulate the gut microbiota to improve health. Capitalizing on gnotobiotic mice (mice with a defined microbiota), the applicant’s group has developed a unique model by which to disentangle the bacterial functions that contribute to biofilm formation in the gastrointestinal tract. Using this model, we have demonstrated that selective biofilm formation in the mouse stomach as a key mechanism by which host specificity is facilitated in the species Lactobacillus reuteri, and have begun to elucidate the molecular processes that underlie formation of biofilms. However, we know little about how these biofilms function and evolve in the context of the mixed species populations that occur in nature.
肠道微生物区系(定植于胃肠道的微生物群落)在人类健康和疾病中发挥着重要作用,但人们对脊椎动物肠道宿主-微生物共生相互作用的基本原理知之甚少。特别是,对多物种肠道生物膜细菌成员之间的相互作用根本没有研究,但这种知识对于制定调节肠道微生物区系以改善健康的策略是必不可少的。利用诺生菌小鼠(具有特定微生物区系的小鼠),申请人的团队开发了一种独特的模型,通过该模型可以解开导致胃肠道生物膜形成的细菌功能。利用这个模型,我们已经证明了小鼠胃中选择性生物膜的形成是促进雷氏乳杆菌宿主专一性的关键机制,并开始阐明生物膜形成的分子过程。然而,我们对这些生物膜如何在自然界中出现的混合物种种群的背景下发挥作用和进化知之甚少。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Walter, Jens其他文献
Microbe Profile: The Lactobacillaceae.
- DOI:
10.1099/mic.0.001414 - 发表时间:
2023-12 - 期刊:
- 影响因子:2.8
- 作者:
Walter, Jens;O'Toole, Paul W. - 通讯作者:
O'Toole, Paul W.
Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome
- DOI:
10.1016/j.chom.2016.09.001 - 发表时间:
2016-10-12 - 期刊:
- 影响因子:30.3
- 作者:
Maldonado-Gomez, Maria X.;Martinez, Ines;Walter, Jens - 通讯作者:
Walter, Jens
Breath volatile metabolome reveals the impact of dietary fibres on the gut microbiota: Proof of concept in healthy volunteers.
- DOI:
10.1016/j.ebiom.2022.104051 - 发表时间:
2022-06 - 期刊:
- 影响因子:11.1
- 作者:
Neyrinck, Audrey M.;Rodriguez, Julie;Zhang, Zhengxiao;Nazare, Julie-Anne;Bindels, Laure B.;Cani, Patrice D.;Maquet, Veronique;Laville, Martine;Bischoff, Stephan C.;Walter, Jens;Delzenne, Nathalie M. - 通讯作者:
Delzenne, Nathalie M.
Bifidobacterium animalis causes extensive duodenitis and mild colonic inflammation in monoassociated interleukin-10-deficient mice.
动物双歧杆菌会导致多丁肾炎和轻度结肠炎症,这是单一相关的白细胞介素-10缺陷小鼠。
- DOI:
10.1002/ibd.20900 - 发表时间:
2009-07 - 期刊:
- 影响因子:4.9
- 作者:
Moran, James P.;Walter, Jens;Tannock, Gerald W.;Tonkonogy, Susan L.;Sartor, R. Balfour - 通讯作者:
Sartor, R. Balfour
Elucidating the role of the gut microbiota in the physiological effects of dietary fiber.
- DOI:
10.1186/s40168-022-01248-5 - 发表时间:
2022-05-13 - 期刊:
- 影响因子:15.5
- 作者:
Deehan, Edward C.;Zhang, Zhengxiao;Riva, Alessandra;Armet, Anissa M.;Perez-Munoz, Maria Elisa;Nguyen, Nguyen K.;Krysa, Jacqueline A.;Seethaler, Benjamin;Zhao, Yuan-Yuan;Cole, Janis;Li, Fuyong;Hausmann, Bela;Spittler, Andreas;Nazare, Julie-Anne;Delzenne, Nathalie M.;Curtis, Jonathan M.;Wismer, Wendy, V;Proctor, Spencer D.;Bakal, Jeffrey A.;Bischoff, Stephan C.;Knights, Dan;Field, Catherine J.;Berry, David;Prado, Carla M.;Walter, Jens - 通讯作者:
Walter, Jens
Walter, Jens的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Walter, Jens', 18)}}的其他基金
Molecular characterization of mixed-species bacterial biofilms in the gastrointestinal tract
胃肠道中混合物种细菌生物膜的分子特征
- 批准号:
RGPIN-2015-05243 - 财政年份:2019
- 资助金额:
$ 3.28万 - 项目类别:
Discovery Grants Program - Individual
Molecular characterization of mixed-species bacterial biofilms in the gastrointestinal tract
胃肠道中混合物种细菌生物膜的分子特征
- 批准号:
RGPIN-2015-05243 - 财政年份:2018
- 资助金额:
$ 3.28万 - 项目类别:
Discovery Grants Program - Individual
Molecular characterization of mixed-species bacterial biofilms in the gastrointestinal tract
胃肠道中混合物种细菌生物膜的分子特征
- 批准号:
RGPIN-2015-05243 - 财政年份:2016
- 资助金额:
$ 3.28万 - 项目类别:
Discovery Grants Program - Individual
Molecular characterization of mixed-species bacterial biofilms in the gastrointestinal tract
胃肠道中混合物种细菌生物膜的分子特征
- 批准号:
RGPIN-2015-05243 - 财政年份:2015
- 资助金额:
$ 3.28万 - 项目类别:
Discovery Grants Program - Individual
相似海外基金
Molecular characterization of mixed-species bacterial biofilms in the gastrointestinal tract
胃肠道中混合物种细菌生物膜的分子特征
- 批准号:
RGPIN-2015-05243 - 财政年份:2019
- 资助金额:
$ 3.28万 - 项目类别:
Discovery Grants Program - Individual
Molecular characterization of mixed-species bacterial biofilms in the gastrointestinal tract
胃肠道中混合物种细菌生物膜的分子特征
- 批准号:
RGPIN-2015-05243 - 财政年份:2018
- 资助金额:
$ 3.28万 - 项目类别:
Discovery Grants Program - Individual
Construction and Characterization of MOF-Nanosheet Based Mixed Matrix Membranes with Two-Dimensional Nano-Confined Molecular Transport Pathways
具有二维纳米限制分子传输途径的基于 MOF-纳米片的混合基质膜的构建和表征
- 批准号:
322912360 - 财政年份:2017
- 资助金额:
$ 3.28万 - 项目类别:
Research Grants
Molecular characterization of mixed-species bacterial biofilms in the gastrointestinal tract
胃肠道中混合物种细菌生物膜的分子特征
- 批准号:
RGPIN-2015-05243 - 财政年份:2016
- 资助金额:
$ 3.28万 - 项目类别:
Discovery Grants Program - Individual
Molecular characterization of mixed-species bacterial biofilms in the gastrointestinal tract
胃肠道中混合物种细菌生物膜的分子特征
- 批准号:
RGPIN-2015-05243 - 财政年份:2015
- 资助金额:
$ 3.28万 - 项目类别:
Discovery Grants Program - Individual
Characterization of mixed microbial communities using molecular biology techniques
使用分子生物学技术表征混合微生物群落
- 批准号:
415532-2011 - 财政年份:2011
- 资助金额:
$ 3.28万 - 项目类别:
University Undergraduate Student Research Awards
Molecular Characterization of Human Tryptophan Hydroxylase 2 (hTPH2)
人色氨酸羟化酶 2 (hTPH2) 的分子表征
- 批准号:
7777375 - 财政年份:1991
- 资助金额:
$ 3.28万 - 项目类别:
Molecular Characterization of Human Tryptophan Hydroxylase 2 (hTPH2)
人色氨酸羟化酶 2 (hTPH2) 的分子表征
- 批准号:
7389459 - 财政年份:1991
- 资助金额:
$ 3.28万 - 项目类别:
Molecular Characterization of Human Tryptophan Hydroxylase 2 (hTPH2)
人色氨酸羟化酶 2 (hTPH2) 的分子表征
- 批准号:
7266800 - 财政年份:1991
- 资助金额:
$ 3.28万 - 项目类别:
Molecular Characterization of Human Tryptophan Hydroxylase 2 (hTPH2)
人色氨酸羟化酶 2 (hTPH2) 的分子表征
- 批准号:
7580886 - 财政年份:1991
- 资助金额:
$ 3.28万 - 项目类别: