Decoding links between the RNA polymerase II C-terminal domain and histone modifications

解码 RNA 聚合酶 II C 端结构域和组蛋白修饰之间的联系

• 批准号: RGPIN-2015-03661
• 负责人: Tanny, Jason
• 金额: $ 2.19万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628938
• 关键词: Decoding; links; between; RNA; polymerase

The RNA polymerase II (RNAPII) elongation complex is a key hub for regulatory pathways controlling gene expression in eukaryotes. Aside from its intrinsic mRNA synthesis function, the RNAPII elongation complex governs co-transcriptional mRNA processing and export, covalent histone modifications, and chromatin structure. The molecular platform coordinating all of these functions is the C-terminal domain (CTD) of the RNAPII large subunit. This eukaryote-specific domain consists of multiple repeats of a conserved heptad motif (Y

RNA聚合酶II(RNAPII)延伸复合体是真核生物基因表达调控途径的关键枢纽。除了其固有的mRNA合成功能外，RNAPII延伸复合体还调控共转录的mRNA处理和输出、共价组蛋白修饰和染色质结构。协调所有这些功能的分子平台是RNAPII大亚基的C末端结构域(CTD)。这个真核生物特有的结构域由保守的七肽基序(Y)的多个重复组成