Role of RNA-binding proteins in regulation of gene expression

RNA结合蛋白在基因表达调控中的作用

• 批准号: RGPIN-2015-06246
• 负责人: Lipshitz, Howard
• 金额: $ 3.28万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628970
• 关键词: Role; RNA; binding; proteins; regulation

Post-transcriptional regulation (PTR) of mRNA stability, localization and translation regulates the spatial and temporal expression of proteins in all cell types and organisms. The widespread nature of PTR is highlighted by the fact that typical eukaryotic genomes encode several hundred RBPs, each of which binds to several hundred transcripts. RBPs recognize three classes of

mRNA稳定性、定位和翻译的转录后调节（PTR）调节所有细胞类型和生物体中蛋白质的空间和时间表达。PTR的广泛性通过典型的真核生物基因组编码几百个RBP的事实而突出，每个RBP结合几百个转录物。限制性商业惯例承认三类