Computational Modeling of Gene Regulation

基因调控的计算模型

• 批准号: RGPIN-2017-06743
• 负责人: ZHANG, ZHAOLEI
• 金额: $ 1.89万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628991
• 关键词: Computational; Modeling; Gene; Regulation

The human genome contains over 22,000 genes, which remarkably is not much more than the single cell budding yeast or a fruit fly. So what makes humans so much more complex? The answer lies in the immensely complex and delicate ways by which the human genes are regulated or turned on and off. Glitches in these regulations often result in protein products being made at a wrong amount or at wrong time or wrong place, which in turn can cause diseases such as cancer. In order to better understand how human cells work and function, it is crucial to understand how each of the 22,000 genes is regulated and how groups of genes are turned on and off to fulfill the required cellular task.

人类基因组包含超过22,000个基因，这与单细胞芽殖酵母或果蝇相比并不多。那么是什么让人类变得如此复杂呢？答案在于人类基因被调节或开启和关闭的极其复杂和微妙的方式。这些规则中的小故障往往会导致蛋白质产品在错误的数量、错误的时间或错误的地点被制造出来，这反过来又会导致癌症等疾病。为了更好地了解人类细胞的工作和功能，了解22,000个基因中的每一个是如何被调节的，以及如何打开和关闭一组基因来完成所需的细胞任务是至关重要的。