Computational Modeling of Gene Regulation

人类基因组包含超过22,000个基因，明显比单细胞发芽酵母或果蝇多不了多少。那么，是什么让人类变得如此复杂呢？答案在于人类基因被调控或开启和关闭的极其复杂和微妙的方式。这些规定中的小故障经常导致蛋白质产品的制造数量错误，或者在错误的时间或错误的地点制造，这反过来可能导致癌症等疾病。为了更好地了解人类细胞的工作和功能，了解22,000个基因中的每一个是如何调控的，以及一组基因是如何开启和关闭以完成所需的细胞任务是至关重要的。

The human genome contains over 22,000 genes, which remarkably is not much more than the single cell budding yeast or a fruit fly. So what makes humans so much more complex? The answer lies in the immensely complex and delicate ways by which the human genes are regulated or turned on and off. Glitches in these regulations often result in protein products being made at a wrong amount or at wrong time or wrong place, which in turn can cause diseases such as cancer. In order to better understand how human cells work and function, it is crucial to understand how each of the 22,000 genes is regulated and how groups of genes are turned on and off to fulfill the required cellular task.