A novel role for the breast cancer 1 protein (BRCA1) in prenatal protection against oxidative DNA damage, embryotoxicity and abnormal postnatal brain function

乳腺癌 1 蛋白 (BRCA1) 在针对氧化 DNA 损伤、胚胎毒性和产后脑功能异常的产前保护中发挥新作用

• 批准号: 371170
• 负责人: Wells Peter G
• 金额: $ 46.81万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-09-01 至 2022-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=371170&lang=en
• 关键词: Autism Spectrum Disorders (Asd); Breast Cancer 1 Protein (Brca1); Embryo And Fetus; Epigenetic Modifications; Fetal Alcohol Spectrum Disorders (Fasd); Neurodevelopmental Disorders; Oxidative Dna Damage; Reactive Oxygen Species

The breast cancer 1 (BRCA1) protein is known to protect against breast cancer. However, we have discovered that during pregnancy BRCA1 also protects fetal mice from DNA damage that can cause birth defects and disorders in brain function after birth. The

乳腺癌1（BRCA1）蛋白已知可以预防乳腺癌。然而，我们已经发现，在怀孕期间，BRCA1也可以保护胎鼠免受DNA损伤，这种损伤可能导致出生缺陷和出生后脑功能障碍。 的