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A novel role for the breast cancer 1 protein (BRCA1) in prenatal protection against oxidative DNA damage, embryotoxicity and abnormal postnatal brain function

A novel role for the breast cancer 1 protein (BRCA1) in prenatal protection against oxidative DNA damage, embryotoxicity and abnormal postnatal brain function
乳腺癌 1 蛋白 (BRCA1) 在针对氧化 DNA 损伤、胚胎毒性和产后脑功能异常的产前保护中发挥新作用
批准号：
371170
负责人：
Wells Peter G
金额：
$46.81万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-09-01 至 2022-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=371170&lang=en
关键词：
Autism Spectrum Disorders (Asd) Breast Cancer 1 Protein (Brca1) Embryo And Fetus Epigenetic Modifications Fetal Alcohol Spectrum Disorders (Fasd) Neurodevelopmental Disorders Oxidative Dna Damage Reactive Oxygen Species

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中文摘要
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英文摘要
The breast cancer 1 (BRCA1) protein is known to protect against breast cancer. However, we have discovered that during pregnancy BRCA1 also protects fetal mice from DNA damage that can cause birth defects and disorders in brain function after birth. The
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Free radical determinants of neurodegenerative disease
  • 批准号：
    225733
  • 项目类别：
    Operating Grants
  • 资助金额：
    $46.08万
  • 财政年份：
    2011
  • 负责人：
    Wells Peter G
  • 依托单位：
    University of Toronto
CIHR team in developmental toxicology
  • 批准号：
    176624
  • 项目类别：
    Operating Grants
  • 资助金额：
    $0.73万
  • 财政年份：
    2008
  • 负责人：
    Wells Peter G
  • 依托单位：
    University of Toronto