Evolutionary, developmental, and physiological genomics of salmonid fishes

鲑鱼的进化、发育和生理基因组学

• 批准号: RGPIN-2017-04017
• 负责人: Danzmann, Roy
• 金额: $ 2.91万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629107
• 关键词: Evolutionary; developmental; physiological; genomics; salmonid

Whole genome duplication (WGD) events where all the chromosomes in each cell undergo a complete doubling to give rise to a completely identical set of genes are now recognized as being potential accelerators of evolutionary change in animals and plants. The fates of new genes that arise from WGD are varied, but most duplicated copies appear destined to become nonfunctional (silenced). We still do not understand why some genes are retained as duplicates for long periods of time as essentially identical copies of one another, while other duplicate genes diverge from one another and acquire new expression patterns and potentially new functions. I use salmonid fishes (trout, salmon, charr) to study the distribution and retention of duplicate genes because they are the most recent vertebrate group to have undergone a WGD event in their ancestry. I contrast the patterns of duplicate gene expression in Arctic charr (

全基因组复制（WGD）事件，其中每个细胞中的所有染色体经历完全加倍以产生完全相同的一组基因，现在被认为是动物和植物进化变化的潜在加速器。由WGD产生的新基因的命运各不相同，但大多数重复的拷贝似乎注定成为无功能的（沉默）。我们仍然不明白为什么有些基因作为重复基因长时间保留，彼此基本相同，而另一些重复基因则彼此不同，并获得新的表达模式和潜在的新功能。我用鲑鱼（鳟鱼，鲑鱼，charr）研究重复基因的分布和保留，因为他们是最近的脊椎动物群体经历了WGD事件在他们的祖先。我对比了北极红点鲑重复基因表达的模式，