Deciphering the reductive pathways in phagosomes and lysosomes.

破译吞噬体和溶酶体中的还原途径。

• 批准号: RGPIN-2017-04147
• 负责人: Yates, Robin
• 金额: $ 2.91万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629158
• 关键词: Deciphering; reductive; pathways; phagosomes; lysosomes.

Phagosomes are organelles that are formed after the engulfment of material by phagocytes such as macrophages and dendritic cells. The lumen of phagosome is a dynamic and complex microenvironment. It is the site of microbial killing, precise proteolytic processing of antigens and the degradation and recycling of macromolecules during tissue remodeling, growth and homeostasis. Despite the importance of the phagosome, there are critical gaps in our understanding of its function and dysfunction. One particular gap is the impact of redox chemistries on phagosomal function.

吞噬小体是巨噬细胞和树突状细胞等吞噬细胞吞噬物质后形成的细胞器。吞噬体腔是一个动态复杂的微环境。在组织重塑、生长和动态平衡期间，它是微生物杀灭、抗原精确蛋白分解处理和大分子降解和循环的场所。尽管吞噬小体很重要，但我们对其功能和功能障碍的理解存在严重差距。一个特别的差距是氧化还原化学对吞噬体功能的影响。