Contribution of phospholipase A2 enzymes in the homeostasis of the immune system

磷脂酶 A2 对免疫系统稳态的贡献

• 批准号: RGPIN-2016-05830
• 负责人: Boilard, Eric
• 金额: $ 2.77万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629278
• 关键词: Contribution; phospholipase; A2; enzymes; homeostasis

The immune system distinguishes the self from the non-self, preventing foreign organisms or other sort of insults from damaging the body. To ensure of its homeostasis, multiple mechanisms tightly regulate the immune system. It is now appreciated that a complex ecosystem of microorganisms, referred to as the microbiota, lives in symbiosis with mammals and modulates immune responses. In our NSERC program, we consider the role of bactericidal enzymes hydrolyzing phospholipids, called phospholipase A2 (PLA2), in the regulation of the immune system.

免疫系统将自我与非自我区分开来，防止外来生物或其他种类的侮辱损害身体。为了确保其稳态，多种机制紧密调节免疫系统。现在认识到，被称为微生物群的微生物的复杂生态系统与哺乳动物共生并调节免疫应答。在我们的NSERC计划中，我们考虑了水解磷脂的杀菌酶（称为磷脂酶A2（PLA2））在免疫系统调节中的作用。