Characterization of Ars2 function in RNA processing

RNA 加工中 Ars2 功能的表征

• 批准号: RGPIN-2015-06811
• 负责人: Howard, Perry
• 金额: $ 2.19万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629309
• 关键词: Characterization; Ars2; function; RNA; processing

The long term goal of my research program is to address how different families of RNA transcripts are recognized and correctly processed to mature RNAs with distinct destinations and functions and to understand how the different types of RNA contribute to stem and progenitor cell behavior. The generation of mature RNA in the nucleus is a highly coordinated multistep process that requires distinct complexes for the biogenesis of different RNA families. RNAPII transcripts include at least 4 different types of RNA, each with its own processing requirements. How different families of RNAPII transcripts are recognized and processed to generate mature RNA is not understood. My lab discovered a gene called

我的研究计划的长期目标是解决如何识别不同家族的RNA转录本，并正确加工成具有不同目的地和功能的成熟RNA，并了解不同类型的RNA如何促进干细胞和祖细胞的行为。成熟RNA在细胞核中的产生是一个高度协调的多步骤过程，不同RNA家族的生物发生需要不同的复合物。RNAPII转录本包括至少4种不同类型的RNA，每种RNA都有自己的加工要求。RNAPII转录本的不同家族如何被识别和加工以产生成熟的RNA尚不清楚。我的实验室发现了一种叫做