Neuro-muscular innervation in neonatal intestinal development

新生儿肠道发育中的神经肌肉神经支配

• 批准号: RGPIN-2015-05614
• 负责人: Blennerhassett, Michael
• 金额: $ 2.48万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629325
• 关键词: Neuro; muscular; innervation; neonatal; intestinal

We look at the development of the neuromuscular layer of the newborn mammalian intestine, which will lengthen many-fold before reaching its adult size. This involves extensive growth of the smooth muscle cells to create the adult form. However, the neurons of the enteric nervous system (ENS), which are all present at birth, must coordinate with this and develop the adult pattern of innervation, as the ENS will eventually regulate the timely contraction and relaxation of the smooth muscle that allows normal digestion.

我们来看看新生哺乳动物肠道神经肌肉层的发育，在达到成年大小之前，它会延长许多倍。这涉及平滑肌细胞的广泛生长以产生成人形式。然而，肠神经系统（ENS）的神经元在出生时就存在，必须与此协调，并发展成成人的神经支配模式，因为ENS最终将调节平滑肌的及时收缩和舒张，使其能够正常消化。