Elucidating the Diverse Biochemical Potency of Human OCT4

阐明人类 OCT4 的多种生化效力

• 批准号: RGPIN-2015-06416
• 负责人: Bhatia, Mickie
• 金额: $ 3.79万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629350
• 关键词: Elucidating; Diverse; Biochemical; Potency; Human

Our proposal is based on our recent discoveries pioneered by our group that define direct human cell fate alteration from one somatic cell to another. Our program now makes the extension and transition to biochemical and chemical methods to control and engineer this process using natural science approaches. We focus on a single transcription factor (TF), human OCT4, which represents the most diverse self-regulating factor controlling transcriptional activation/repression. OCT4 has been described as being restricted to preimplantation embryos and germ cells, and plays a critical role in embryonic stem cells and induction of pluripotency from mature cells activating native OCT4, known as induced pluripotent stem cells.

我们的建议是基于我们最近的发现，由我们的小组率先定义直接人类细胞的命运改变从一个体细胞到另一个。我们的项目现在扩展和过渡到生物化学和化学方法，使用自然科学方法控制和设计这一过程。我们专注于一个单一的转录因子（TF），人OCT 4，它代表了最多样化的自我调节因子控制转录激活/抑制。OCT 4被描述为仅限于植入前胚胎和生殖细胞，并且在胚胎干细胞和从激活天然OCT 4的成熟细胞诱导多能性（称为诱导多能干细胞）中起关键作用。