Regulation of Mesenchymal Stem Cell Differentiation by Chemerin/CMKLR1

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Mesenchymal stem cells (MSCs) are multipotent stromal cells with the ability to differentiate into several specialized cell types including bone forming osteoblasts and fat storing adipocytes. During MSC differentiation, global gene expression profiles change such that genes associated with multipotency are repressed and those required for the specialized cell phenotype are activated. This requires the coordinated action chromatin remodeling enzymes such as histone acetyltransferases/deacetylases (HATs/HDACs). These proteins also affect the function of key transcription factors associated with specific lineages through post-translational modification. We have identified a secreted protein, chemerin, which exerts a powerful influence on MSC differentiation by activating a cell surface receptor termed chemokine-like receptor 1 (CMKLR1). We have shown that