Regulation of Mesenchymal Stem Cell Differentiation by Chemerin/CMKLR1

Chemerin/CMKLR1 对间充质干细胞分化的调节

• 批准号: RGPIN-2017-06492
• 负责人: Sinal, Christopher
• 金额: $ 1.89万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629366
• 关键词: Regulation; Mesenchymal; Stem; Cell; Differentiation

Mesenchymal stem cells (MSCs) are multipotent stromal cells with the ability to differentiate into several specialized cell types including bone forming osteoblasts and fat storing adipocytes. During MSC differentiation, global gene expression profiles change such that genes associated with multipotency are repressed and those required for the specialized cell phenotype are activated. This requires the coordinated action chromatin remodeling enzymes such as histone acetyltransferases/deacetylases (HATs/HDACs). These proteins also affect the function of key transcription factors associated with specific lineages through post-translational modification. We have identified a secreted protein, chemerin, which exerts a powerful influence on MSC differentiation by activating a cell surface receptor termed chemokine-like receptor 1 (CMKLR1). We have shown that

间充质干细胞（Mesenchymal stem cell，MSCs）是一种多能的基质细胞，具有分化成骨细胞和脂肪细胞的能力。在MSC分化过程中，全局基因表达谱发生变化，使得与多能性相关的基因被抑制，而特化细胞表型所需的基因被激活。这需要协调作用的染色质重塑酶，如组蛋白乙酰转移酶/脱乙酰酶（HAT/HDAC）。这些蛋白质还通过翻译后修饰影响与特定谱系相关的关键转录因子的功能。我们已经确定了一种分泌蛋白，chemerin，它通过激活称为趋化因子样受体1（CMKLR 1）的细胞表面受体对MSC分化产生强大的影响。我们已经证明