Role of microRNAs in synovial fibroblast biology and functions

microRNA 在滑膜成纤维细胞生物学和功能中的作用

• 批准号: RGPIN-2017-06360
• 负责人: Kapoor, Mohit
• 金额: $ 2.04万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629386
• 关键词: Role; microRNAs; synovial; fibroblast; biology

Synovial fibroblasts are predominant cells present in the synovial membrane and are crucial for the maintenance of joint homeostasis by contributing towards the production of extracellular matrix (ECM). Synovial fibroblasts in response to specific stimuli (cytokines and growth factors) acquire myofibroblast-type phenotype and produce excessive amount of ECM resulting in tissue fibrosis and loss of function. The endogenous mediators that control synovial fibroblast functions (differentiation, migration, proliferation and adhesion) and ECM production are largely unknown. MicroRNAs (miRNAs) are small non-coding RNAs that regulate more than 60% of all coding genes and play pivotal roles in various pathophysiological processes. The exact role of microRNAs in synovial fibroblast biology and functions is largely unknown.

滑膜成纤维细胞是存在于滑膜中的主要细胞，并且通过促进细胞外基质（ECM）的产生而对维持关节稳态至关重要。滑膜成纤维细胞响应于特定刺激（细胞因子和生长因子）获得肌成纤维细胞型表型并产生过量的ECM，导致组织纤维化和功能丧失。控制滑膜成纤维细胞功能（分化、迁移、增殖和粘附）和ECM产生的内源性介质在很大程度上尚不清楚。microRNAs（miRNAs）是一类小分子非编码RNA，调控着60%以上的编码基因，在多种病理生理过程中发挥着重要作用。microRNA在滑膜成纤维细胞生物学和功能中的确切作用在很大程度上是未知的。