Signaling events regulating microglial functions and activation phenotypes

调节小胶质细胞功能和激活表型的信号事件

• 批准号: RGPIN-2017-05934
• 负责人: Kauppinen, Tiina
• 金额: $ 1.89万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629404
• 关键词: Signaling; events; regulating; microglial; functions

Microglia are the immune cells of brain, which they protect from pathogens. In addition, microglial phagocytosis activity, cytokine production, and trophic factor secretion regulate neuronal plasticity, the key phenomenon that allows brain to reorganize its neural connections in response to new situations. While modulated microglial activity is beneficial, dysregulated microglial actions can cause neuronal dysfunction and promote cognitive deficits and neuronal death. These opposite roles of microglia are feasible because of their diverse functions attributed to specific activation phenotypes.

小胶质细胞是大脑的免疫细胞，它们保护大脑免受病原体的侵袭。此外，小胶质细胞的吞噬活性、细胞因子的产生和营养因子的分泌调节神经元的可塑性，这是允许大脑重组其神经连接以应对新情况的关键现象。虽然调节的小胶质细胞活动是有益的，但调节失调的小胶质细胞活动会导致神经元功能障碍，并促进认知障碍和神经元死亡。小胶质细胞的这些相反作用是可行的，因为它们的不同功能归因于特定的激活表型。