Regulation of EGF receptor trafficking fate by phosphorylation and Odin

点击翻译按钮获取中文摘要

Binding of growth factors to receptors is a key mechanism that regulates the growth and development of metazoans. Epidermal growth factor receptor (EGFR) is a prototypical growth factor receptor. Activated EGFR is rapidly internalization by endocytosis. Internalized EGFR either recycle back to the cell surface or degrade in lysosomes as a consequence of a trafficking sorting switch. EGFR also internalize and recycle in response to cellular stresses. These processes control receptor density at the cell surface, and in turn signaling responses to diverse ligand concentration gradients and environmental cues, which are highly variable in metazoans.