Regulation of EGF receptor trafficking fate by phosphorylation and Odin

通过磷酸化和 Odin 调节 EGF 受体运输命运

• 批准号: RGPIN-2016-06305
• 负责人: Moran, Michael
• 金额: $ 2.77万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629427
• 关键词: Regulation; EGF; receptor; trafficking; fate

Binding of growth factors to receptors is a key mechanism that regulates the growth and development of metazoans. Epidermal growth factor receptor (EGFR) is a prototypical growth factor receptor. Activated EGFR is rapidly internalization by endocytosis. Internalized EGFR either recycle back to the cell surface or degrade in lysosomes as a consequence of a trafficking sorting switch. EGFR also internalize and recycle in response to cellular stresses. These processes control receptor density at the cell surface, and in turn signaling responses to diverse ligand concentration gradients and environmental cues, which are highly variable in metazoans.

生长因子与受体的结合是调节后生动物生长和发育的关键机制。表皮生长因子受体（EGFR）是一种典型的生长因子受体。活化的EGFR通过内吞作用迅速内化。内化的EGFR或者再循环回到细胞表面，或者作为运输分选开关的结果在溶酶体中降解。EGFR还响应于细胞应激而内化和再循环。这些过程控制细胞表面的受体密度，并反过来对不同的配体浓度梯度和环境线索发出信号反应，这在后生动物中是高度可变的。