Impact of BHV-1 tegument proteins on the innate response to infection and virion morphogenesis.

BHV-1 外皮蛋白对感染和病毒颗粒形态发生的先天反应的影响。

• 批准号: RGPIN-2016-06230
• 负责人: vanDrunenLittelvandenHurk, Sylvia
• 金额: $ 3.21万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629470
• 关键词: Impact; BHV; tegument; proteins; innate

Bovine herpesvirus-1 (BoHV-1) has a severe impact on growth, milk production, and international livestock trade, thus being responsible for major economic damage to the cattle industry worldwide. In North America BoHV-1 is part of the bovine respiratory disease complex, which costs the cattle industry >1 billion dollars each year. In addition, BoHV-1 is an emerging virus in buffalo. Herpesviruses are composed of four concentric compartments, the nucleoprotein core, capsid, tegument and envelope. Tegument proteins are the first to interact with the intracellular environment and at a later stage associate to create the tegument of new virions. Some herpesvirus tegument proteins have important functions, for instance in regulation of transcription and in virus morphogenesis. The mechanism and site of BoHV-1 tegument formation, and the functions of its protein components are largely unknown.

牛疱疹病毒-1(BoHV-1)对牛的生长、牛奶生产和国际牲畜贸易造成严重影响，从而对全球养牛业造成重大经济损失。在北美，BoHV-1是牛呼吸道疾病复合体的一部分，每年给养牛业造成10亿美元的损失。此外，BoHV-1是水牛中出现的一种新病毒。疱疹病毒由核蛋白核心、衣壳、被膜和包膜四个同心隔室组成。被膜蛋白首先与细胞内环境相互作用，在后来的阶段形成新的病毒粒子的被层。一些疱疹病毒被膜蛋白具有重要的功能，例如在转录调控和病毒形态发生中。BoHV-1被膜形成的机制和部位，以及其蛋白质组分的功能在很大程度上尚不清楚。