Mechanisms and Regulation of Rhomboid Intramembrane Proteolysis

菱形膜内蛋白水解的机制和调控

• 批准号: RGPIN-2015-04645
• 负责人: Munter, Lisa
• 金额: $ 2.55万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629491
• 关键词: Mechanisms; Regulation; Rhomboid; Intramembrane; Proteolysis

During evolution, species acquired new genes through gene duplication as well as through modifications. Obviously, there are substantial evolutionary differences between kingdoms of life such as bacteria, archaea, fungi, plantae and animals. Despite these diversities, it is remarkable that some proteins were conserved in all kingdoms throughout evolution and can be found in mammals as well as in the common bacteria

在进化过程中，物种通过基因复制和修饰获得了新基因。显然，细菌、古细菌、真菌、植物和动物等生命界之间存在着巨大的进化差异。尽管存在这些多样性，但值得注意的是，一些蛋白质在整个进化过程中在所有王国中都是保守的，并且可以在哺乳动物和常见细菌中找到