Polarity complexes in cellular differentiation

细胞分化中的极性复合物

• 批准号: RGPIN-2017-05146
• 负责人: Fawcett, James
• 金额: $ 2.04万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629506
• 关键词: Polarity; complexes; cellular; differentiation

My NSERC Discovery program has focused on identifying protein-protein complexes that regulate cell polarity. In particular we have been focusing on the role of these complexes play in the development of the synapse, one of the more polarized structures in the CNS. Synapses are sites of cell-cell contact specialized for the transmission of chemical and electrical signals between neurons. The specialized function of the synapse results from the asymmetric distribution of proteins forming the presynaptic and postsynaptic compartments, and involves the coordinated regulation of actin dynamics. Not surprisingly then, signalling pathways that regulate the activity of the small Rho GTPases, Rac, Rho and cdc42, have been shown to play an important role in the development and maintenance of the synapse and synaptic morphology.

我的NSERC发现计划专注于识别调节细胞极性的蛋白质-蛋白质复合物。特别是，我们一直专注于这些复合物在突触发育中的作用，突触是中枢神经系统中更极化的结构之一。突触是细胞与细胞接触的部位，专门用于神经元之间的化学和电信号传输。突触的特殊功能是由形成突触前和突触后区室的蛋白质的不对称分布引起的，并且涉及肌动蛋白动力学的协调调节。因此，毫不奇怪，调节小Rho GTP酶Rac、Rho和cdc 42活性的信号传导途径已被证明在突触和突触形态的发育和维持中起重要作用。