MET and p66SHC interactomes and functions

MET 和 p66SHC 相互作用组和功能

• 批准号: RGPIN-2017-06704
• 负责人: Saucier, Caroline
• 金额: $ 1.89万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629516
• 关键词: MET; p66SHC; interactomes; functions

The integrity of the intestinal epithelium of the digestive tract is ensured by its rapid renewal. This involves spatiotemporal coordinated proliferation, migration, differentiation and survival of various intestinal epithelial cells (IEC). These cellular processes are dictated by growth factor signals produced by IECs and adjacent cells. Hepatocyte growth factor (HGF) is a molecule promoting and maintaining tissue organization in various organs by activating the receptor tyrosine kinase (RTK) MET in epithelial cells. Several lines of evidence suggest that the MET/HGF receptor axis may play a key role in the renewal of the intestinal epithelium, but the early embryonic death of HGF- or MET-deficient mice have greatly limited its study.

消化道的肠上皮的完整性通过其快速更新来确保。这涉及各种肠上皮细胞（IEC）的时空协调增殖、迁移、分化和存活。这些细胞过程由IEC和相邻细胞产生的生长因子信号决定。肝细胞生长因子（HGF）是一种通过激活上皮细胞中的受体酪氨酸激酶（RTK）MET来促进和维持各种器官组织结构的分子。一些证据表明，MET/HGF受体轴可能在肠上皮细胞的更新中发挥关键作用，但HGF或MET缺陷小鼠的早期胚胎死亡极大地限制了其研究。