MET and p66SHC interactomes and functions

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The integrity of the intestinal epithelium of the digestive tract is ensured by its rapid renewal. This involves spatiotemporal coordinated proliferation, migration, differentiation and survival of various intestinal epithelial cells (IEC). These cellular processes are dictated by growth factor signals produced by IECs and adjacent cells. Hepatocyte growth factor (HGF) is a molecule promoting and maintaining tissue organization in various organs by activating the receptor tyrosine kinase (RTK) MET in epithelial cells. Several lines of evidence suggest that the MET/HGF receptor axis may play a key role in the renewal of the intestinal epithelium, but the early embryonic death of HGF- or MET-deficient mice have greatly limited its study.