Alterations of Wnt, Akt and Yap signalling during bi-directional epithelial-mesenchymal transitions

双向上皮间质转化过程中 Wnt、Akt 和 Yap 信号传导的变化

• 批准号: RGPIN-2017-05020
• 负责人: Wang, Lisheng
• 金额: $ 2.04万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629562
• 关键词: Alterations; Wnt; Akt; Yap; signalling

– Bi-directional epithelial-mesenchymal transitions (EMT/MET) are fundamental cellular processes essential for normal mammalian embryonic development and adult cell homeostasis and functions. While the majority of studies thus far focus on how growth factors, extracellular signals, transcriptional factors, and intracellular signaling pathways regulate EMT/MET, a fundamental question that have been largely overlooked and yet to be answered is whether and how dynamic EMT/MET, in turn, affect their regulators to co-control embryonic development and adult cell homeostasis and functions. This will be the long-term goal of our

- 双向上皮-间充质转化（EMT/MET）是哺乳动物胚胎发育和成体细胞稳态和功能所必需的基本细胞过程。虽然迄今为止大多数研究都集中在生长因子、细胞外信号、转录因子和细胞内信号通路如何调节EMT/MET，但一个基本问题在很大程度上被忽视，尚未得到回答的是动态EMT/MET是否以及如何反过来影响其调节因子以共同控制胚胎发育和成体细胞稳态和功能。这将是我们的长期目标。