Alterations of Wnt, Akt and Yap signalling during bi-directional epithelial-mesenchymal transitions

点击翻译按钮获取中文摘要

– Bi-directional epithelial-mesenchymal transitions (EMT/MET) are fundamental cellular processes essential for normal mammalian embryonic development and adult cell homeostasis and functions. While the majority of studies thus far focus on how growth factors, extracellular signals, transcriptional factors, and intracellular signaling pathways regulate EMT/MET, a fundamental question that have been largely overlooked and yet to be answered is whether and how dynamic EMT/MET, in turn, affect their regulators to co-control embryonic development and adult cell homeostasis and functions. This will be the long-term goal of our