The role of STAT1 signaling in persistent intestinal viral infection

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Accumulating data demonstrates that the species that colonize our intestine – ranging from microscopic viruses and bacteria up to multicellular eukaryotic helminthic parasites – can exert strong influences over multiple physiological systems, including nutrient metabolism, local and systemic immune responses, metabolic regulation and cognitive function. However, fundamental gaps in our understanding of how these diverse systems are regulated by intestinal colonizing species remain. Thus,