The role of STAT1 signaling in persistent intestinal viral infection

STAT1信号在持续性肠道病毒感染中的作用

• 批准号: RGPIN-2016-04282
• 负责人: Osborne, Lisa
• 金额: $ 2.77万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629547
• 关键词: role; STAT1; signaling; persistent; intestinal

Accumulating data demonstrates that the species that colonize our intestine – ranging from microscopic viruses and bacteria up to multicellular eukaryotic helminthic parasites – can exert strong influences over multiple physiological systems, including nutrient metabolism, local and systemic immune responses, metabolic regulation and cognitive function. However, fundamental gaps in our understanding of how these diverse systems are regulated by intestinal colonizing species remain. Thus,

越来越多的数据表明，定植于我们肠道的物种--从微小的病毒和细菌到多细胞真核寄生虫--可以对多种生理系统产生强烈的影响，包括营养代谢、局部和全身免疫反应、代谢调节和认知功能。然而，在我们对肠道定植物种如何调控这些不同系统的理解中，仍然存在根本的差距。因此，