Role of Misshappen (NIK/Msn) kinases and Extended-Synaptotagmins (E-Syts) in Wnt and FGF intracellular signaling pathways.

点击翻译按钮获取中文摘要

Signalling between cells is fundamental to determining the metazoan body plan and in controlling growth and differentiation. Hence, a large number of families of signalling molecules and their cognate receptors have evolved to enable the complexities of early development, organogensis and homeostasis. Several of these families are of importance during early development, in particular the Wingless (Wnt) and Fibroblast Growth Factors (FGFs) families. These play separate, but interrelated, roles during development and act through distinct as well as shared transduction pathways. We have identified novel elements of the FGF and Wnt signalling pathways that provide potential windows into important aspects of signalling and inter-pathway crosstalk. We propose mechanistic studies that will provide new insight into the complex network of intracellular signalling.