Role of Misshappen (NIK/Msn) kinases and Extended-Synaptotagmins (E-Syts) in Wnt and FGF intracellular signaling pathways.

畸形 (NIK/Msn) 激酶和扩展突触结合蛋白 (E-Syts) 在 Wnt 和 FGF 细胞内信号传导通路中的作用。

• 批准号: RGPIN-2017-06128
• 负责人: Moss, Thomas
• 金额: $ 2.91万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629577
• 关键词: Role; Misshappen; NIK; Msn; kinases

Signalling between cells is fundamental to determining the metazoan body plan and in controlling growth and differentiation. Hence, a large number of families of signalling molecules and their cognate receptors have evolved to enable the complexities of early development, organogensis and homeostasis. Several of these families are of importance during early development, in particular the Wingless (Wnt) and Fibroblast Growth Factors (FGFs) families. These play separate, but interrelated, roles during development and act through distinct as well as shared transduction pathways. We have identified novel elements of the FGF and Wnt signalling pathways that provide potential windows into important aspects of signalling and inter-pathway crosstalk. We propose mechanistic studies that will provide new insight into the complex network of intracellular signalling.

细胞之间的信号传导对于决定后生动物的身体计划以及控制生长和分化是至关重要的。因此，大量家族的信号分子和它们的同源受体已经进化，使早期发育，器官发生和稳态的复杂性。这些家族中的几个在早期发育期间是重要的，特别是无翼（Wnt）和成纤维细胞生长因子（FGF）家族。它们在发育过程中发挥独立但相互关联的作用，并通过不同的和共享的转导途径发挥作用。我们已经确定了FGF和Wnt信号通路的新元件，这些元件为信号通路和通路间串扰的重要方面提供了潜在的窗口。我们提出了机制的研究，将提供新的见解复杂的细胞内信号网络。