Thalamic gating during sleep oscillations

睡眠振荡期间的丘脑门控

• 批准号: RGPIN-2017-06135
• 负责人: Timofeev, Igor
• 金额: $ 2.48万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629614
• 关键词: Thalamic; gating; during; sleep; oscillations

: I am interested in the understanding of physiological basis of conscious states, which is essentially a cortical phenomenon. Almost all information reaching cerebral cortex passes through the thalamus, which is a key element in the understanding of cortical function. Morphology and physiology of sensory thalamus and thalamocortical system (somatosensory, visual etc) is known. However, the role of midline thalamic nuclei (MTN) remains largely obscure. Neurons from these nuclei are likely responsible for the generation of conscious vs. unconscious states and different levels of alertness. I propose to investigate not only how these neurons are implicated in the generation of brain states, but also how a modification of their excitability could affect behavioral performance.

我感兴趣的是理解意识状态的生理基础，这本质上是一种皮层现象。几乎所有到达大脑皮层的信息都要经过丘脑，这是理解大脑皮层功能的一个关键因素。感觉丘脑和丘脑皮质系统（体感、视觉等）的形态学和生理学是已知的。然而，中线丘脑核（MTN）的作用在很大程度上仍然不清楚。来自这些核的神经元可能负责产生有意识和无意识状态以及不同程度的警觉性。我建议不仅要研究这些神经元如何与大脑状态的产生有关，还要研究它们的兴奋性的改变如何影响行为表现。