Binding of Endophilin Endocytic Proteins to AMPA Receptors and Neuronal Voltage-gated Potassium (Kv) Channels: Regulation of Synaptic Plasticity

这项发现基金专注于离子通道的细胞生物学，以及神经组织兴奋性和学习记忆的调节。电压门控钾(Kv)通道和配体门控谷氨酸受体(AMPAR)分别在人脑中执行许多功能，包括维持静息膜电位和调节形成记忆的突触可塑性。Kv-家族钾通道的几个成员，即Kv1.5、Kv4.2和Herg通道，以及AMPAR在大脑的一个称为海马体的区域表达，海马体负责编码和存储记忆。

This Discovery Grant is focused on the cellular biology of ion channels and regulation of nervous tissue excitability and learning and memory. The voltage-gated potassium (Kv) channels and ligand-gated glutamate receptors called AMPARs perform many functions in the human brain, including maintenance of resting membrane potential and regulation of memory-forming synaptic plasticity, respectively. Several members of the Kv-family of potassium channels, namely the Kv1.5, Kv4.2 and HERG channels, and AMPARs are expressed in an area of the brain, called the hippocampus, which is responsible for encoding and storing memory.