Linking T cell receptor sequence to T cell function

将 T 细胞受体序列与 T 细胞功能联系起来

• 批准号: RGPIN-2016-03808
• 负责人: Mandl, Judith
• 金额: $ 2.62万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629790
• 关键词: Linking; cell; receptor; sequence; function

T cells are critical effector cells of the adaptive immune system which recognize foreign antigen in the form of peptides presented by host cell major histocompatibility complexes (MHC). Each T cell bears a unique antigen recognition receptor, the T cell receptor (TCR), which determines the exquisite specificity and the affinity with which an individual T cell binds peptide-MHC. The TCR is generated through rearrangement of germline encoded gene segments and the addition of non-templated (non-germline encoded) nucleotides by an enzyme called terminal deoxynucleotidyl transferase (TdT). The interaction strength between the TCR and peptide-MHC is a critical parameter in all T cell fate decisions, from selection in the thymus during development to differentiation during infection. Yet, due to the enormous diversity of TCRs that can be made (>10

T细胞是适应性免疫系统的关键效应细胞，其识别由宿主细胞主要组织相容性复合物（MHC）呈递的肽形式的外来抗原。每个T细胞具有独特的抗原识别受体，即T细胞受体（TCR），其决定单个T细胞结合肽-MHC的精确特异性和亲和力。TCR通过种系编码的基因片段的重排和通过称为末端脱氧核苷酸转移酶（TdT）的酶添加非模板化（非种系编码）核苷酸来产生。TCR和肽-MHC之间的相互作用强度是所有T细胞命运决定的关键参数，从发育期间胸腺中的选择到感染期间的分化。然而，由于可以制造的TCR的巨大多样性（>10