Molecular Regulation of Inflammatory Cytokine Production in Macrophages

巨噬细胞炎症细胞因子产生的分子调控

• 批准号: RGPIN-2017-05941
• 负责人: Uzonna, Jude
• 金额: $ 1.89万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629805
• 关键词: Molecular; Regulation; Inflammatory; Cytokine; Production

An important function of the host immune system is to initiate an inflammatory response that is required to control foreign insults and initiate tissue repair. The inflammatory process is normally self-limiting and regulated in order to avoid collateral self-damage. A dysregulation of inflammation results in excessive and persistent inflammation. A characteristic feature of uncontrolled inflammation is elevated expression of certain cytokines collectively known as proinflammatory cytokines. Myeloid immune cells (particularly macrophages and neutrophils) play important roles in inflammation via their production of inflammatory mediators including cytokines. The molecular mechanisms controlling inflammation have not been fully delineated.

宿主免疫系统的一个重要功能是启动炎症反应，这是控制外来损伤和启动组织修复所需的。炎症过程通常是自我限制和调节的，以避免附带的自我损伤。炎症的失调导致过度和持续的炎症。不受控制的炎症的特征是某些细胞因子（统称为促炎细胞因子）的表达升高。髓样免疫细胞（特别是巨噬细胞和嗜中性粒细胞）通过其产生包括细胞因子的炎性介质在炎症中起重要作用。控制炎症的分子机制尚未完全阐明。