Regulation of chromatin topology

染色质拓扑的调节

• 批准号: RGPIN-2015-03719
• 负责人: Nelson, Christopher
• 金额: $ 3.28万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629852
• 关键词: Regulation; chromatin; topology

Chromatin is an essential mixture of DNA and protein that packages the genome. Several different forms of chromatinized DNA exist in cells, and these states determine which DNA sequences are read and which are silenced. This is perhaps the most critical decision to be made in a cell: the consequent gene expression profile (which genes are ‘ON’ and which genes are ‘OFF’) is the key determinant of cellular identity and behavior. Learning how chromatin states are established and regulated is therefore relevant to broad scientific fields including the studies of the regulation of cell growth, cell and organism development and environment-disease relationships.

染色质是包装基因组的 DNA 和蛋白质的重要​​混合物。细胞中存在几种不同形式的染色质 DNA，这些状态决定了哪些 DNA 序列被读取，哪些被沉默。这可能是细胞中要做的最关键的决定：随后的基因表达谱（哪些基因“开启”，哪些基因“关闭”）是细胞身份和行为的关键决定因素。因此，了解染色质状态如何建立和调节与广泛的科学领域相关，包括细胞生长调节、细胞和生物体发育以及环境与疾病关系的研究。