Transcriptional programmes downstream of the activated glucocorticoid receptor

激活的糖皮质激素受体下游的转录程序

• 批准号: RGPIN-2016-04549
• 负责人: Newton, Robert
• 金额: $ 2.4万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629886
• 关键词: Transcriptional; programmes; downstream; activated; glucocorticoid

BACKGROUND: This mechanism-based study is designed, by way of training high quality personnel (HQP), to characterise and promote understanding of the gene expression networks induced by the glucocorticoid receptor (GR/NR3C1). During stress, cortisol (a glucocorticoid) is produced by the adrenal cortex and is carried in the blood to target tissues. There, it acts on GR, a transcription factor that promotes breakdown of macromolecules to help maintain blood glucose during fasting and starvation. In infection and injury, glucocorticoids play a key survival role by reducing expression of mediators to dampen inflammation and promoting healing. Research, in my laboratory, focuses on how glucocorticoids act via GR to induce the expression of genes that are responsible for repressing inflammation. As lung epithelial cells are an important site of environmental insult and infection, they are used to model glucocorticoid-modulated gene expression.

背景技术背景：本研究旨在通过培养高素质人才（HQP）的方式，探索和促进对糖皮质激素受体（GR/NR 3C 1）诱导的基因表达网络的理解。在压力下，皮质醇（一种糖皮质激素）由肾上腺皮质产生，并通过血液运送到目标组织。在那里，它作用于GR，一种促进大分子分解的转录因子，以帮助在禁食和饥饿期间维持血糖。在感染和损伤中，糖皮质激素通过减少介质的表达来抑制炎症和促进愈合，从而发挥关键的生存作用。在我的实验室里，研究的重点是糖皮质激素如何通过GR来诱导负责抑制炎症的基因的表达。由于肺上皮细胞是环境损伤和感染的重要部位，因此它们被用于模拟糖皮质激素调节的基因表达。