Biogenesis of outermembrane proteins in Gram-negative bacteria

革兰氏阴性菌外膜蛋白的生物发生

• 批准号: RGPIN-2017-06091
• 负责人: Calmettes, Charles
• 金额: $ 2.26万
• 依托单位: Institut national de la recherche scientifique
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629950
• 关键词: Biogenesis; outermembrane; proteins; Gram; negative

The double membrane surrounding each Gram-negative bacteria protects the bacteria from its environment, and is the site of many other essential functions such as nutriment acquisition, cell-signaling, adhesion, motility, virulence, or bacterial reproduction. The proteins in these membranes are of critical importance as the functions they accomplish are required for cell survival and bacterial pathogenesis. While the biogenesis of inner-membrane proteins has been studied over decades and is well described in the literature, the mechanisms underlying the incorporation and biogenesis of integral membrane proteins within the bacterial outer-membrane remain elusive. These mechanisms are of critical importance as they are used by pathogenic bacteria to cover themselves with cell surface proteins promoting virulence, and thus are considered promising drug targets for the development of novel therapeutics against bacterial pathogens.

围绕每个革兰氏阴性菌的双层膜保护细菌免受其环境的影响，并且是许多其他基本功能的场所，例如营养物质获取，细胞信号传导，粘附，运动性，毒性或细菌繁殖。这些膜中的蛋白质至关重要，因为它们完成的功能是细胞存活和细菌致病所必需的。虽然内膜蛋白的生物发生已经研究了几十年，并在文献中有很好的描述，整合膜蛋白在细菌外膜内的整合和生物发生的机制仍然难以捉摸。这些机制是至关重要的，因为它们被病原性细菌用来用促进毒力的细胞表面蛋白覆盖自身，因此被认为是开发针对细菌病原体的新型治疗剂的有前景的药物靶标。