Pharmacological chaperones that bind F508del-CFTR and their mechanisms of action

结合 F508del-CFTR 的药理学伴侣及其作用机制

• 批准号: 370768
• 负责人: Hanrahan John W
• 金额: $ 67.6万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-09-01 至 2022-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=370768&lang=en
• 关键词: Cystic Fibrosis; Er Chaperones; Er Regulation; Human Primary Bronchial Epithelial Cells; Mechanisms Of Action; Medicinal Compound Synergy; Pharmacological Chaperones; Protein Trafficking Disease; Protein-Protein Interactions; Sites Of Action

Proteins are string-like molecules that play many vital roles in the human body. They are made up of about 20 different building blocks called amino acids, which are in a particular sequence that enables the string to fold up into its correct 3 dimension

蛋白质是在人体中起着许多重要作用的线状分子。 它们由大约20种不同的称为氨基酸的构建块组成，这些氨基酸以特定的顺序排列，使字符串能够折叠成正确的三维空间