Structure, function, and regulation of Thrombin-Activatable Fibrinolysis Inhibitor (TAFI)

凝血酶激活纤溶抑制剂 (TAFI) 的结构、功能和调节

• 批准号: RGPIN-2017-05571
• 负责人: Boffa, Michael
• 金额: $ 1.89万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630022
• 关键词: Structure; function; regulation; Thrombin; Activatable

Thrombin-activatable fibrinolysis inhibitor (TAFI) is a protein found in blood plasma that regulates blood clot breakdown, a process known as fibrinolysis. Our proposal seeks to investigate the mechanisms of how TAFI is activated and how its activity is turned off. Together, these events control the function of TAFI in normal physiology (such as prevention of bleeding) and in disease (such as the development of heart attack and strokes).

凝血酶活化纤维蛋白溶解抑制剂（TAFI）是一种在血浆中发现的蛋白质，可调节血凝块分解，这一过程被称为纤维蛋白溶解。我们的建议旨在研究TAFI如何被激活以及它的活性如何被关闭的机制。总之，这些事件控制TAFI在正常生理（如预防出血）和疾病（如心脏病发作和中风的发展）中的功能。