Metabolic activation of arylamines, nitroaromatics, and related mutagens

芳胺、硝基芳族化合物和相关诱变剂的代谢激活

• 批准号: RGPIN-2017-05200
• 负责人: Josephy, Philip
• 金额: $ 1.89万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630030
• 关键词: Metabolic; activation; arylamines; nitroaromatics; related

The focus of my research program is Molecular Toxicology. Our long-term goal is to understand the biochemical mechanisms that lead from exposure of a cell to a chemical to the ultimate toxic consequences of that exposure - e.g., induction of mutations, the raw material for evolutionary change. Most environmental mutagens are metabolized to DNA-reactive electrophiles. Consequently, I approach toxicology through biochemistry - especially, characterizing the enzymes that catalyze mutagen biotransformation. Fundamental questions about the metabolism and toxicology of aromatic amines, azo dyes, and nitroaromatic compounds (many of which are carcinogens) remain unanswered, but modern analytical and molecular-biological technologies are bringing the answers within reach.

我的研究项目的重点是分子毒理学。我们的长期目标是了解从细胞暴露于化学物质到暴露的最终毒性后果的生化机制-例如，诱导突变，进化变化的原材料。大多数环境诱变剂被代谢为DNA反应性亲电体。因此，我通过生物化学方法处理毒理学-特别是，表征催化诱变剂生物转化的酶。关于芳香胺、偶氮染料和硝基芳香化合物（其中许多是致癌物）的代谢和毒理学的基本问题仍然没有答案，但现代分析和分子生物学技术正在使答案触手可及。