Discovering mechanisms of gene regulation in plant cell specific transcriptomes using bioinformatics and microgenomics

利用生物信息学和微观基因组学发现植物细胞特异性转录组中的基因调控机制

• 批准号: RGPIN-2015-04571
• 负责人: Stromvik, Martina
• 金额: $ 2.04万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630277
• 关键词: Discovering; mechanisms; gene; regulation; plant

Functional cells and organs are the products of an amazing collection of tens of thousands of genes, orchestrated by different levels of regulation. At the most basic level, each gene’s possibility of expression is controlled by gene switches, regulatory sequence motifs, to which proteins called transcription factors bind. These regulatory motifs and combinations of them probably exists in the thousands, however, the exact number is unknown. Few of them are well-known or well-studied, yet they are crucial for development of functional cells, organs and organisms.

功能性细胞和器官是由成千上万个基因组成的惊人集合的产物，这些基因由不同水平的调控精心编排。在最基本的水平上，每个基因表达的可能性都是由基因开关控制的，基因开关是一种调控序列基序，被称为转录因子的蛋白质与之结合。这些调控基序和它们的组合可能存在于数千个，然而，确切的数量是未知的。它们中很少有人是众所周知的或经过充分研究的，但它们对功能细胞，器官和生物体的发育至关重要。