Mechanisms Underlying the Survival of Adult Generated Neurons

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The brain possesses an innate ability to generate new neurons from dividing neural precursor cells throughout adulthood. Surprisingly, of the thousands of cells that are generated, the vast majority of them die as they mature, thus proliferation of precursor cells only results in a few newly generated neurons. In order to manipulate or promote neurons to survive and signal within the brain, it is imperative to better understand the molecular pathways that regulate NPC survival.