Mechanisms Underlying the Survival of Adult Generated Neurons

成体神经元存活的机制

• 批准号: RGPIN-2015-03638
• 负责人: Lagace, Diane
• 金额: $ 2.4万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630432
• 关键词: Mechanisms; Underlying; Survival; Adult; Generated

The brain possesses an innate ability to generate new neurons from dividing neural precursor cells throughout adulthood. Surprisingly, of the thousands of cells that are generated, the vast majority of them die as they mature, thus proliferation of precursor cells only results in a few newly generated neurons. In order to manipulate or promote neurons to survive and signal within the brain, it is imperative to better understand the molecular pathways that regulate NPC survival.

大脑拥有一种天生的能力，可以在整个成年期从分裂的神经前体细胞中产生新的神经元。令人惊讶的是，在生成的数千个细胞中，绝大多数细胞在成熟时死亡，因此前体细胞的增殖只会导致少数新生成的神经元。为了操纵或促进神经元在大脑中存活和发出信号，必须更好地了解调节NPC存活的分子途径。