Neurobiology of peptidergic and aminergic neurons in insects.

昆虫肽能和胺能神经元的神经生物学。

• 批准号: RGPIN-2017-06402
• 负责人: Orchard, Ian
• 金额: $ 5.03万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630453
• 关键词: Neurobiology; peptidergic; aminergic; neurons; insects.

The central theme of my research program is the functioning of the nervous system, using insects as experimental models. We are establishing the mechanisms by which the nervous system communicates information; examining hormonal, synaptic, and modulatory mechanisms, using neurophysiological, neurochemical, endocrinological, and molecular biological techniques. The questions we are asking are fundamentally important for all nervous systems: How can a neuron transmit information to a target cell? What types of chemicals act as the transmitters for this information and how are these chemical messages translated by the target cell? How can this information be modulated and coordinated to produce an appropriate behaviour in the animal? In particular, we are interested in the role of peptides and amines as neurohormones, released into the blood to co-ordinate activities of diverse groups of tissues, and as neuromodulators, modulating the ongoing activities of distinct pathways.

我的研究项目的中心主题是神经系统的功能，使用昆虫作为实验模型。我们正在建立神经系统传递信息的机制；使用神经生理学、神经化学、内分泌学和分子生物学技术检查激素、突触和调节机制。我们提出的问题对于所有神经系统都至关重要：神经元如何将信息传递到目标细胞？哪些类型的化学物质充当该信息的传递者以及目标细胞如何翻译这些化学信息？如何调节和协调这些信息以使动物产生适当的行为？我们特别感兴趣的是肽和胺作为神经激素的作用，释放到血液中以协调不同组织群的活动，以及作为神经调节剂，调节不同途径的持续活动。