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The Maternal Environment: Influence on Early Mammalian Development

The Maternal Environment: Influence on Early Mammalian Development
母体环境：对哺乳动物早期发育的影响
批准号：
RGPIN-2016-04740
负责人：
Watson, Andrew
金额：
$2.26万
依托单位：
University of Western Ontario
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-01-01 至 2018-12-31
来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630472
关键词：
MaternalEnvironmentInfluenceEarlyMammalian

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英文摘要
Principal Objective: Our discovery research will focus on understanding the impact of energy stress metabolism on HIPPO pathway directed cell fate determination during preimplantation development. We will determine whether trophectoderm (TE) and inner cell mass (ICM) cell lineages in the blastocyst vary in their energy metabolism and whether this variation affects differential activation of HIPPO pathway signaling that results in TE differentiation and maintenance of ICM pluripotency. Our hypothesis is that energy metabolism via control of AMPK regulates cell lineage specification via hippo pathway activation during preimplantation development.
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The Maternal Environment: Influence on Early Mammalian Development
  • 批准号：
    RGPIN-2016-04740
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $2.26万
  • 财政年份：
    2021
  • 负责人：
    Watson, Andrew
  • 依托单位：
    University of Western Ontario
The Maternal Environment: Influence on Early Mammalian Development
  • 批准号：
    RGPIN-2016-04740
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $2.26万
  • 财政年份：
    2020
  • 负责人：
    Watson, Andrew
  • 依托单位：
    University of Western Ontario
The Maternal Environment: Influence on Early Mammalian Development
  • 批准号：
    RGPIN-2016-04740
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $2.26万
  • 财政年份：
    2019
  • 负责人：
    Watson, Andrew
  • 依托单位：
    University of Western Ontario
The Maternal Environment: Influence on Early Mammalian Development
  • 批准号：
    RGPIN-2016-04740
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $2.26万
  • 财政年份：
    2018
  • 负责人：
    Watson, Andrew
  • 依托单位：
    University of Western Ontario
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