The gut epithelium as a target organ of ingested metals: investigating Cd-induced ERK activation and the related impatcs on intestinal function in vitro and in vivo

肠道上皮作为摄入金属的靶器官：研究镉诱导的 ERK 激活及其对体外和体内肠道功能的相关影响

• 批准号: RGPIN-2017-05106
• 负责人: Jumarie, Catherine
• 金额: $ 1.82万
• 依托单位: Université du Québec à Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630477
• 关键词: gut; epithelium; target; organ; ingested

Cadmium (Cd) is a toxic metal with many industrial uses that is present in atmosphere, run off water, soil and sediment. It is absorbed through inhalation (in work places and for tobacco smokers), and ingestion of contaminated food products. Cadmium is poorly eliminated and it remains in the body. Its toxicity includes pulmonary obstructive diseases, kidney dysfunction, and osteomalacia (bones softening). Cd is also a carcinogen. It is listed by the US Environmental Protection Agency as well as by Environment and Health Canada as one of priority pollutants.

镉 (Cd) 是一种具有多种工业用途的有毒金属，存在于大气、径流水、土壤和沉积物中。它通过吸入（在工作场所和吸烟者）和摄入受污染的食品而被吸收。镉很难被清除，并且残留在体内。其毒性包括肺阻塞性疾病、肾功能障碍和骨软化症（骨质软化）。镉也是一种致癌物质。它被美国环境保护署和加拿大环境与健康部列为优先污染物之一。